Abstract
Programmed cell death 4 (Pdcd4) is a tumor suppressor, which has been demonstrated to efficiently suppress tumorigenesis. Biochemically, Pdcd4 binds with translation initiation factor 4A and represses protein translation. Beyond its role in tumor suppression, growing evidence suggests that Pdcd4 enhances the chemosensitivity of several anticancer drugs. To date, numerous translational targets of Pdcd4 have been identified. These targets govern important signal transduction pathways, and their attenuation may improve chemosensitivity or overcome drug resistance. This review will discuss the signal transduction pathways regulated by Pdcd4 and the potential mechanisms through which Pdcd4 enhances chemosensitivity or counteracts drug resistance.
Document Type
Article
Publication Date
10-2024
Digital Object Identifier (DOI)
https://doi.org/10.3390/ph17101396
Funding Information
This work was partially supported by National Cancer Institute grants CA272483 and CA279455.
Repository Citation
Wang, Qing and Yang, Hsin-Sheng, "The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance" (2024). Markey Cancer Center Faculty Publications. 242.
https://uknowledge.uky.edu/markey_facpub/242
Included in
Medicinal and Pharmaceutical Chemistry Commons, Oncology Commons, Other Medical Sciences Commons, Pharmaceutics and Drug Design Commons
Notes/Citation Information
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).