Collagen is the major component of extracellular matrix. Collagen cross-link and deposition depend on lysyl hydroxylation, which is catalyzed by procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD). Aberrant lysyl hydroxylation and collagen cross-link contributes to the progression of many collagen-related diseases, such as fibrosis and cancer. Three lysyl hydroxylases (LH1, LH2, and LH3) are identified, encoded by PLOD1, PLOD2, and PLOD3 genes. Expression of PLODs is regulated by multiple cytokines, transcription factors and microRNAs. Dysregulation of PLODs promotes cancer progression and metastasis, suggesting that targeting PLODs is potential strategy for cancer treatment. Here, we summarize the recent progress in the investigation of function and regulation of PLODs in normal tissue development and disease progression, especially in cancer.
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This study was supported by funding support from NCI (1R01CA207772, 1R01CA215095, and 1R21CA209045 to RX) and United States Department of Defense (W81XWH-15-1-0052 to RX).
Qi, Yifei and Xu, Ren, "Roles of PLODs in Collagen Synthesis and Cancer Progression" (2018). Markey Cancer Center Faculty Publications. 108.