Abstract
New-onset jaundice can be a manifestation of multiple pathologic processes including hemolysis, parenchymal liver disease, and cholestasis; the differential diagnosis is broad and requires a systematic approach. We report a case of a patient who presented with jaundice after starting minocycline for the treatment of acne vulgaris and rapidly developed fulminant liver failure found to be due to Wilson's disease. She also manifested severe Coomb's negative hemolytic anemia and renal failure secondary to hepatorenal syndrome. As a bridge to liver transplant, she was successfully treated with plasmapheresis to decrease serum copper in addition to hemodialysis for acidosis and hyperkalemia. She was able to receive a liver and made a full recovery. The case highlights the use of plasmapheresis as an adjunctive treatment modality in cases of fulminant liver failure due to Wilson's disease.
Document Type
Article
Publication Date
9-9-2014
Digital Object Identifier (DOI)
http://dx.doi.org/10.1155/2014/672985
Repository Citation
Hilal, Talal and Morehead, R. Scott, "Fulminant Wilson's Disease Managed with Plasmapheresis as a Bridge to Liver Transplant" (2014). Internal Medicine Faculty Publications. 57.
https://uknowledge.uky.edu/internalmedicine_facpub/57
Notes/Citation Information
Published in Case Reports in Medicine, v. 2014, article ID 672985, p. 1-4.
Copyright © 2014 Talal Hilal and R. Scott Morehead. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.