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Abstract
We describe a rare case of knee osteonecrosis in a 22-year-old man with astrocytoma and neurofibromatosis type 1 after short-term treatment with bevacizumab and corticosteroids. Magnetic resonance imaging (MRI) identified infarctions and osteonecrosis of the distal femur and proximal tibia. Osteonecrosis associated with bevacizumab is typically limited to the jaw; this case highlights the potential for earlier, extra-jaw involvement. Clinicians should maintain a high index of suspicion for osteonecrosis in patients on vascular endothelial growth factor inhibitors, especially with concurrent steroid use, and consider prompt MRI in the evaluation of unexplained joint pain.
Document Type
Article
Publication Date
2025
Digital Object Identifier (DOI)
https://doi.org/10.7326/aimcc.2025.0613
Repository Citation
Kakarala, Chandra L.; Lisek, Nicole A.; Coleman, Clyde; Villano, John L.; Copely, Katherine L.; and Santos, Patricia A., "Early-Onset Bevacizumab-Associated Knee Osteonecrosis in a Young Adult With Astrocytoma" (2025). Internal Medicine Faculty Publications. 295.
https://uknowledge.uky.edu/internalmedicine_facpub/295
Notes/Citation Information
© 2025 Authors. Published in partnership by the American College of Physicians and American Heart Association
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