Abstract
Hepatic epithelioid hemangioendothelioma (HEH) is an unusual, low-grade malignant vascular tumor of the liver. Here we describe a case of a 40-year-old woman who presented with abdominal pain in the upper right quadrant and giant hepatomegaly, in which imaging studies and a fine-needle liver biopsy confirmed the presence of a large EHE with an isolated lung metastasis. After balancing all possible therapeutic modalities the patient was treated conservatively with thalidomide (300 mg/day). The drug was well tolerated with minimal toxicity and thepatient continues on therapy 109 months after treatment was started with no disease progression. Current therapeutic options for HEH are discussed in light of the clinical case with particular emphasis on anti-angiogenic therapies.
Document Type
Article
Publication Date
6-21-2019
Digital Object Identifier (DOI)
https://doi.org/10.1016/S1665-2681(19)31596-0
Repository Citation
Salech, Felipe; Valderrama, Sebastián; Nervi, Bruno; Rodriguez, Juan Carlos; Oksenberg, Danny; Koch, Alvaro; Smok, Gladys; Duarte, Ignacio; Pérez-Ayuso, Rosa María; Jarufe, Nicolás; Martínez, Jorge; Soza, Alejandro; Arrese, Marco; and Riquelme, Arnoldo, "Thalidomide for the Treatment of Metastatic Hepatic Epithelioid Hemangioendothelioma: A Case Report with a Long Term Follow-up" (2019). Internal Medicine Faculty Publications. 254.
https://uknowledge.uky.edu/internalmedicine_facpub/254
Notes/Citation Information
Published in Annals of Hepatology, v. 10, issue 1.
Copyright © 2011 Fundación Clínica Médica Sur, A.C.
This is an open access article under the CC BY-NC-ND
license (https://creativecommons.org/licenses/by-nc-nd/4.0/).