Abstract
Background: Patients with chronic kidney disease (CKD) have an increased risk of osteoporotic fractures, which is due not only to low bone volume and mass but also poor microarchitecture and tissue quality. The pharmacological and nonpharmacological interventions detailed, herein, are potential approaches to improve bone health in CKD patients. Various medications build up bone mass but also affect bone tissue quality. Antiresorptive therapies strikingly reduce bone turnover; however, they can impair bone mineralization and negatively affect the ability to repair bone microdamage and cause an increase in bone brittleness. On the other hand, some osteoporosis therapies may cause a redistribution of bone structure that may improve bone strength without noticeable effect on BMD. This may explain why some drugs can affect fracture risk disproportionately to changes in BMD. Summary: An accurate detection of the underlying bone abnormalities in CKD patients, including bone quantity and quality abnormalities, helps in institution of appropriate management strategies. Here in this part II, we are focusing on advancements in bone therapeutics that are anticipated to improve bone health and decrease mortality in CKD patients. Key Messages: Therapeutic interventions to improve bone health can potentially advance life span. Emphasis should be given to the impact of various therapeutic interventions on bone quality.
Document Type
Review
Publication Date
4-26-2021
Digital Object Identifier (DOI)
https://doi.org/10.1159/000515542
Related Content
Asadipooya, K., Abdalbary, M., Ahmad, Y., Kakani, E., Monier-Faugere, M.-C., & El-Husseini, A. (2021). Bone quality in ckd patients: Current concepts and future directions – Part I. Kidney Diseases, 7, 1-10. https://doi.org/10.1159/000515534
The above article is also available from UKnowledge.
Repository Citation
Asadipooya, Kamyar; Abdalbary, Mohamed; Ahmad, Yahya; Kakani, Elijah; Monier-Faugere, Marie-Claude; and El-Husseini, Amr, "Bone Quality in Chronic Kidney Disease Patients: Current Concepts and Future Directions – Part II" (2021). Internal Medicine Faculty Publications. 249.
https://uknowledge.uky.edu/internalmedicine_facpub/249
Included in
Endocrinology, Diabetes, and Metabolism Commons, Internal Medicine Commons, Nephrology Commons
Notes/Citation Information
Published in Kidney Diseases.
© 2021 The Author(s) Published by S. Karger AG, Basel
This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.