Abstract
Critical illness polyneuropathy/critical illness myopathy (CIP/CIM) is a major cause of mortality and long-term morbidity in critically ill patients, but the true incidence and prevalence of these syndromes are not known. Hermans and colleagues show that when intensive insulin therapy is used as part of routine clinical practice in the intensive care unit, the incidence of CIP/CIM as determined by electrophysiologic testing is reduced. Our understanding of the mechanisms responsible for inducing prolonged weakness in intensive care unit patients is limited, and the role of hyperglycemia in modulating these processes is unknown. Intensive insulin therapy currently remains the only effective therapeutic intervention that has been shown to reduce the incidence of CIP/CIM.
Document Type
Response or Comment
Publication Date
3-26-2009
Digital Object Identifier (DOI)
http://dx.doi.org/10.1186/cc7728
Repository Citation
Callahan, Leigh Ann and Supinski, Gerald S., "Hyperglycemia and acquired weakness in critically ill patients: potential mechanisms" (2009). Internal Medicine Faculty Publications. 24.
https://uknowledge.uky.edu/internalmedicine_facpub/24
Notes/Citation Information
Published in Critical Care, v. 13, 125.
© 2009 BioMed Central Ltd
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.