Abstract
Hypercalcemia in patients with cancer is a common laboratory finding affecting up to 44% of that patient population. 1,25-Dihydroxyvitamin D3 mediated hypercalcemia is one of the rare mechanisms of this endocrine emergency in cancer patients. It is even rarer for solid organ neoplasms to present with hypercalcemia mediated through the production of 1,25-dihydroxyvitamin D3. We report a case of a 77-year-old female who presented to the hospital with hypercalcemia and later was found to have metastatic gastrointestinal stromal tumor. There have been only 5 cases of gastrointestinal stromal tumor described in literature resulting in hypercalcemia. In our case, the mechanism of hypercalcemia was thought to be related to overproduction of 1,25-dihydroxyvitamin by tumor cells. The patient had a favorable response to imatinib with normalization of serum calcium level. Unfortunately, she developed fluid retention due to imatinib which was discontinued resulting in relapse of hypercalcemia that was resistant to all other treatment options.
Document Type
Article
Publication Date
4-6-2017
Digital Object Identifier (DOI)
https://doi.org/10.1155/2017/4972017
Repository Citation
Barbaryan, Aram; Bailuc, Stefania; Poddutoori, Padma; Richardson, Aida; and Mirrakhimov, Aibek E., "Gastrointestinal Stromal Tumor Induced Hypercalcemia" (2017). Internal Medicine Faculty Publications. 129.
https://uknowledge.uky.edu/internalmedicine_facpub/129
Included in
Endocrine System Diseases Commons, Gastroenterology Commons, Internal Medicine Commons, Oncology Commons
Notes/Citation Information
Published in Case Reports in Oncological Medicine, v. 2017, 4972017, p. 1-4.
© 2017 Aram Barbaryan et al.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.