Synthesis and Characterization of Tripodal-Imidazolium and Pyridazine Ruthenium Complexes and Their Associated Ligands

Author

Jacqueline L. Kowalke, University of KentuckyFollow

Year of Publication

2020

College

Arts and Sciences

Department/School/Program

Chemistry

Degree Name

Bachelor of Science in Chemistry

First Capstone/Thesis Advisor

Dr. John P. Selegue

Abstract

Photochemical therapy (PCT) is a relatively new treatment for cancer. PCT, unlike photodynamic therapy (PDT), does not require oxygen though it may be one of the mechanisms that the photosensitizer uses to destroy cancerous cells. Ruthenium complexes have recently entered clinical trials for the treatment of cancer. TLD1433, a ruthenium coordination complex, has entered phase II clinical trials for the treatment of non-muscular invasive bladder cancer. In this compound, the ligands are coordinated via nitrogen bonds, but in this paper, carbon-coordinated complexes are explored. Coordination of N-heterocyclic carbene (NHC) ligands to ruthenium is suspected to provide a different type of coordination complex in PCT. Tripodal and pyridazine NHC ligands were synthesized in this paper, with the tripodal ligand being more successfully produced.

Recommended Citation

Kowalke, Jacqueline L., "Synthesis and Characterization of Tripodal-Imidazolium and Pyridazine Ruthenium Complexes and Their Associated Ligands" (2020). Lewis Honors College Capstone Collection. 45.
https://uknowledge.uky.edu/honprog/45