Abstract
Since its first description more than 20 years ago osteopontin has emerged as an active player in many physiological and pathological processes, including biomineralization, tissue remodeling and inflammation. As an extracellular matrix protein and proinflammatory cytokine osteopontin is thought to facilitate the recruitment of monocytes/macrophages and to mediate cytokine secretion in leukocytes. Modulation of immune cell response by osteopontin has been associated with various inflammatory diseases and may play a pivotal role in the development of adipose tissue inflammation and insulin resistance. Here we summarize recent findings on the role of osteopontin in metabolic disorders, particularly focusing on diabetes and obesity.
Document Type
Review
Publication Date
7-2014
Digital Object Identifier (DOI)
http://dx.doi.org/10.1016/j.molmet.2014.03.004
Repository Citation
Kahles, Florian; Findeisen, Hannes M.; and Bruemmer, Dennis, "Osteopontin: A Novel Regulator at the Cross Roads of Inflammation, Obesity and Diabetes" (2014). Gill Heart & Vascular Institute Faculty Publications. 3.
https://uknowledge.uky.edu/heart_facpub/3
Notes/Citation Information
Published in Molecular Metabolism, v. 3, no. 4, p. 384-393.
© 2014 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/)