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Abstract
Oxidized LDL induces changes in several facets of the immune system, although the relationships between these facets and their contributions to atherogenesis have yet to be fully elucidated. A report in this issue of the JCI provides a novel demonstration of the adaptive immune system influencing the production of natural antibodies. The results demonstrate that injection of malondialdehyde-modified LDL promotes a Th2 response that in turn increases the titers of the natural antibody T15/EO6, which recognizes the oxidized phospholipid POVPC. Atherosclerotic lesion size in LDL receptor–deficient mice is reduced as a consequence of the increase in natural antibody titers, and IL-5 is identified as the link between the adaptive and natural immune systems.
Document Type
Article
Publication Date
8-1-2004
Digital Object Identifier (DOI)
https://doi.org/10.1172/JCI22561
Repository Citation
Daugherty, Alan; Rateri, Debra L.; and King, Victoria L., "IL-5 Links Adaptive and Natural Immunity in Reducing Atherosclerotic Disease" (2004). Gill Heart & Vascular Institute Faculty Publications. 29.
https://uknowledge.uky.edu/heart_facpub/29
Notes/Citation Information
Published in The Journal of Clinical Investigation, v. 114, no. 3.
© 2004 The American Society for Clinical Investigation
The copyright holder has granted the permission for posting the article here.