Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To deflne the scope and duration of its pharmacological responses after oral administration, 6 horses were dosed with isoxsuprine HCI (1.2 mg/kg bwt) q. 12 h for 8 days and then tested to assess the duration and extent of pharmacological actions. There was no significant difference between isoxsuprine and control treatment values for heart rate, spontaneous activity, sweat production, anal muscle tone, core and skin temperatures, and cutaneous blood flow. The lack of pharmacological effect following oral administration was in sharp contrast to the marked response following i.v. dosing reported in earlier experiments.

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Notes/Citation Information

Published as #225 from the Equine Pharmacology and Experimental Therapeutics Program at the Maxwell H. Gluck Equine Research Center and the Department of Veterinary Science, University of Kentucky. Published as Kentucky Agricultural Experiment Station Article #96-14-142 with the approval of the Dean and Director, College of Agriculture and Kentucky Agricultural Experiment Station.

Funding Information

Supported by grants from the Kentucky Racing Commission and the Kentucky Equine Drug Council, Lexington, Kentucky, the National and Florida offices of the Horsemen's Benevolent and Protective Association, Aventura, Florida, the Grayson-Jockey Club Research Foundation, Lexington, Kentucky and Mrs J. Hay Whitney.