Date Available
5-2-2014
Year of Publication
2014
Document Type
Doctoral Dissertation
Degree Name
Doctor of Philosophy (PhD)
College
Engineering
Department/School/Program
Electrical Engineering
Advisor
Dr. J. Todd Hastings
Abstract
Noble metal nanoparticles supporting localized surface plasmon resonances (LSPR) have been extensively investigated for label free detection of various biological and chemical interactions. When compared to other optical sensing techniques, LSPR sensors offer label-free detection of biomolecular interactions in localized sensing volume solutions. However, these sensors also suffer from a major disadvantage – LSPR sensors remain highly susceptible to interference because they respond to both solution refractive index change and non-specific binding as well as specific binding of the target analyte. These interactions can severely compromise the measurement of the target analyte in a complex unknown media and hence limit the applicability and impact of the sensor. In spite of the extensive amount of work done in this field, there has been a clear absence of efforts to make LSPR sensors immune to interfering effects. The work presented in this document investigates, both experimentally and numerically, dual- and tri-mode LSPR sensors that utilize the multiple surface plasmon modes of gold nanostructures to distinguish target analyte from interfering bulk and non-specific binding effects. Finally, a series of biosensing experiments are performed to examine various regeneration assays for LSPR sensors built on indium tin oxide coated glass substrate.
Recommended Citation
Nehru, Neha, "Reference Compensation for Localized Surface-Plasmon Resonance Sensors" (2014). Theses and Dissertations--Electrical and Computer Engineering. 41.
https://uknowledge.uky.edu/ece_etds/41
Included in
Biomedical Commons, Electromagnetics and Photonics Commons, Nanoscience and Nanotechnology Commons, Nanotechnology Fabrication Commons, Optics Commons
