Calcium, Vitamin D, and Risk for Colorectal Adenoma: Dependency on Vitamin D Receptor BsmI Polymorphism and Nonsteroidal Anti-Inflammatory Drug Use?

Authors

Sonia M. Boyapati, Vanderbilt University
Roberd M. Bostick, University of South Carolina - ColumbiaFollow
Katherine A. McGlynn, National Cancer InstituteFollow
Michael F. Fina, Forsyth Medical Center
Walter M. Roufail, Wake Forest University
Kim R. Geisinger, Wake Forest UniversityFollow
Michael Wargovich, University of South Carolina - ColumbiaFollow
Ann L. Coker, University of Texas Health Science Center at HoustonFollow
James R. Hebert, University of South Carolina - ColumbiaFollow

Abstract

Previous epidemiological studies have been inconclusive in demonstrating an inverse association among calcium, vitamin D, and risk for colorectal adenoma. The purpose of this analysis was to evaluate the associations among calcium and vitamin D and risk for incident, sporadic colorectal adenoma according to the vitamin D receptor BsmI polymorphism and nonsteroidal anti-inflammatory drug (NSAID) use. We analyzed data from a colonoscopy-based case-control study (n = 177 cases, 228 controls) conducted in North Carolina between 1995 and 1997. Adjusted odds ratios (ORs) comparing participants in the highest to those in the lowest tertiles of total calcium and vitamin D intakes were 0.64 [95% confidence interval (CI), 0.35–1.15], P_trend = 0.14 and 0.69 (95% CI, 0.41–1.18), and P_trend = 0.19, respectively. Adjusted ORs for those in the upper tertile of total calcium intake relative to those in the lower were 0.25 (95% CI, 0.08–0.80) among those who had a Bb genotype, 0.57 (95% CI, 0.18–1.82) among those who had a bb genotype, and 0.36 (95% CI, 0.15–0.85) among those who did not take NSAIDs. The ORs for the highest tertile of calcium intake was 0.05 (95% CI, 0.01–0.41), P_trend < 0.01 among those who were Bb and did not take NSAIDs, and 0.16 (95% CI, 0.02–1.36), P_trend = 0.47 among those who were bb and did not take NSAIDs. These data support the hypotheses that higher calcium intakes may decrease risk for colorectal neoplasms, and that such a relationship is more readily detectable among those who do not take NSAIDs, and may be strongest among those who have at least one vitamin D receptor BsmI b allele.

Document Type

Article

Publication Date

7-2003

Notes/Citation Information

Published in Cancer Epidemiology, Biomarkers & Prevention, v. 12, no. 7, p. 631-637.

Dr. Ann Coker had not been a faculty member of the University of Kentucky at the time of publication.

Repository Citation

Boyapati, Sonia M.; Bostick, Roberd M.; McGlynn, Katherine A.; Fina, Michael F.; Roufail, Walter M.; Geisinger, Kim R.; Wargovich, Michael; Coker, Ann L.; and Hebert, James R., "Calcium, Vitamin D, and Risk for Colorectal Adenoma: Dependency on Vitamin D Receptor BsmI Polymorphism and Nonsteroidal Anti-Inflammatory Drug Use?" (2003). CRVAW Faculty Journal Articles. 207.
https://uknowledge.uky.edu/crvaw_facpub/207