CRVAW Faculty Journal Articles
Archived
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Abstract
An unusual behavioral and cardiovascular reaction was observed during opioid blockade with naltrexone in a 32-year-old male who met DSM III-R criteria for post-traumatic stress disorder (PTSD). As part of an ongoing placebo-controlled investigation of the effects of naltrexone on laboratory and ambulatory blood pressure reactivity, this participant reported experiencing feelings of rage, explosive behavior, and other unpleasant symptoms. When compared to all other subjects (N=24), this individual showed significantly greater effects of naltrexone on blood pressure reactivity during the laboratory stressor. His ambulatory blood pressures, when compared to placebo, were significantly increased during the 24-hr period following naltrexone. The unusual behavioral and cardiovascular responses following ingestion of naltrexone suggest an important role for endogenous opioids in adjustment to stress in this case of PTSD.
Document Type
Article
Publication Date
1994
Digital Object Identifier (DOI)
http://dx.doi.org/10.1007/BF02102950
Repository Citation
Ibarra, Paloma; Bruehl, Stephen P.; McCubbin, James A.; Carlson, Charles R.; Wilson, John F.; Norton, Jane A.; and Montgomery, Thomas B., "An Unusual Reaction to Opioid Blockade with Naltrexone in a Case of Posttraumatic Stress Disorder" (1994). CRVAW Faculty Journal Articles. 165.
https://uknowledge.uky.edu/crvaw_facpub/165
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Anesthesia and Analgesia Commons, Mental and Social Health Commons, Psychiatry and Psychology Commons
