An Unusual Reaction to Opioid Blockade with Naltrexone in a Case of Posttraumatic Stress Disorder

Authors

Paloma Ibarra, University of Kentucky
Stephen P. Bruehl, Vanderbilt UniversityFollow
James A. McCubbin, Clemson UniversityFollow
Charles R. Carlson, University of KentuckyFollow
John F. Wilson, University of KentuckyFollow
Jane A. Norton, University of Kentucky
Thomas B. Montgomery, University of South AlabamaFollow

Abstract

An unusual behavioral and cardiovascular reaction was observed during opioid blockade with naltrexone in a 32-year-old male who met DSM III-R criteria for post-traumatic stress disorder (PTSD). As part of an ongoing placebo-controlled investigation of the effects of naltrexone on laboratory and ambulatory blood pressure reactivity, this participant reported experiencing feelings of rage, explosive behavior, and other unpleasant symptoms. When compared to all other subjects (N=24), this individual showed significantly greater effects of naltrexone on blood pressure reactivity during the laboratory stressor. His ambulatory blood pressures, when compared to placebo, were significantly increased during the 24-hr period following naltrexone. The unusual behavioral and cardiovascular responses following ingestion of naltrexone suggest an important role for endogenous opioids in adjustment to stress in this case of PTSD.

Document Type

Article

Publication Date

1994

Digital Object Identifier (DOI)

http://dx.doi.org/10.1007/BF02102950

Repository Citation

Ibarra, Paloma; Bruehl, Stephen P.; McCubbin, James A.; Carlson, Charles R.; Wilson, John F.; Norton, Jane A.; and Montgomery, Thomas B., "An Unusual Reaction to Opioid Blockade with Naltrexone in a Case of Posttraumatic Stress Disorder" (1994). CRVAW Faculty Journal Articles. 165.
https://uknowledge.uky.edu/crvaw_facpub/165