Date Available
7-15-2024
Year of Publication
2024
Document Type
Master's Thesis
Degree Name
Master of Science in Chemical Engineering (MSChE)
College
Engineering
Department/School/Program
Chemical and Materials Engineering
Advisor
Dr. Thomas Dziubla
Abstract
Smart biomaterials are becoming promising for therapeutic deliveries due to their ability to respond to changes in the environment. Redox-responsive hydrogels are a promising type of smart polymer that can swell and degrade according to cellular oxidative stress levels. Glutathione, abundant in cells, is crucial in redox-responsive biomaterials, serving as a key reactive molecule. This study explored the degradation kinetics of glutathione-responsive poly(β-amino ester) (PBAE) polymers created through a single-step Michael addition. We examined how disulfide content influences the degradation kinetics of these PBAE networks. Additionally, we investigated how the hydrophilicity and functionality of acrylate affect the degradation of disulfide-containing PBAE systems. These redox-sensitive materials were tested under nearly physiological conditions of reduced glutathione to determine its effects on the swelling and degradation behavior of disulfide-containing PBAE polymers. Based on these findings, we developed disulfide-containing PBAE nanogels.
Digital Object Identifier (DOI)
https://doi.org/10.13023/etd.2024.353
Recommended Citation
Aronova, Anastasiia, "DEVELOPMENT OF GLUTATHIONE-RESPONSIVE DISULFIDE-CONTAINING POLY(BETA-AMINO ESTERS) WITH VARIED HYDROPHILICITY AND ACRYLATE FUNCTIONALITY" (2024). Theses and Dissertations--Chemical and Materials Engineering. 168.
https://uknowledge.uky.edu/cme_etds/168
Included in
Biochemical and Biomolecular Engineering Commons, Biological Engineering Commons, Biomaterials Commons, Polymer Science Commons
