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US Patent Number
5800991
Publication Date
9-1-1998
Abstract
Sites on antibodies having affinity for photoaffinity compounds, in particular purine or azidopurine containing compounds are taught. Such photoaffinity sites are contained on a conserved region of different antibody molecules. These sites provide for the site-specific attachment of nucleotide photoaffinity compounds to antibodies, e.g., ATP- or GTP-analog photoaffinity compounds by photochemical means. These nucleotide photoaffinity compounds may additionally be attached to molecules having a desired therapeutic or diagnostic activity, and the resultant conjugates used as diagnostics or therapeutics.
Assignees
University of Kentucky Research Foundation, Lexington, Ky.
Application Number
681,432
Filing Date
07/23/1996
Recommended Citation
Haley, Boyd E.; Köhler, Heinz; Rajagopalan, Krishnan; and Pavlinkova, Gabriela, "Nucleotide or Nucleoside Photoaffinity Compound Modified Antibodies, Methods for Their Manufacture and Use Thereof as Diagnostics and Therapeutics" (1998). Chemistry Faculty Patents. 29.
https://uknowledge.uky.edu/chemistry_patents/29
