Functional utility of gold complexes with phosphorus donor ligands in biological systems

Authors

• Adedamola S. Arojojoye, University of KentuckyFollow
• Samuel G. Awuah, University of KentuckyFollow

Abstract

Metallo-phosphines are ubiquitous in organometallic chemistry with widespread applications as catalysts in various chemical transformations, precursors for organic electronics, and chemotherapeutic agents or chemical probes. Here, we provide a comprehensive review of the exploration of the current biological applications of Au complexes bearing phosphine donor ligands. The goal is to deepen our understanding of the synthetic utility and reactivity of Au-phosphine complexes to provide insights that could lead to the design of new molecules and enhance the cross-application or repurposing of these complexes.

Document Type

Article

Publication Date

2025

Notes/Citation Information

0010-8545/© 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Digital Object Identifier (DOI)

https://doi.org/10.1016/j.ccr.2024.216208

Funding Information

This work and S.G.A. was supported by grant R01CA258421-01 from the National Cancer Institute and NSF Grant No. 2203559.

Repository Citation

Arojojoye, Adedamola S. and Awuah, Samuel G., "Functional utility of gold complexes with phosphorus donor ligands in biological systems" (2025). Chemistry Faculty Publications. 207.
https://uknowledge.uky.edu/chemistry_facpub/207