Comparative Proteomic Analyses of the Parietal Lobe from Rhesus Monkeys Fed a High-Fat/Sugar Diet With and Without Resveratrol Supplementation, Relative to a Healthy Diet: Insights Into the Roles of Unhealthy Diets and Resveratrol on Function

Authors

Aaron M. Swomley, University of KentuckyFollow
Judy C. Triplett, University of KentuckyFollow
Jeriel T. Keeney, University of KentuckyFollow
Govind Warrier, University of Kentucky
Kevin J. Pearson, University of KentuckyFollow
Julie A. Mattison, National Institute on Aging
Rafael de Cabo, National Institute on Aging
Jian Cai, University of Louisville
Jon B. Klein, University of Louisville
D. Allan Butterfield, University of KentuckyFollow

Abstract

A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. Our results contribute to a better understanding of the mechanisms by which resveratrol functions through the up- or down-regulation of proteins in different cellular sub-systems to affect the overall health of the brain.

Document Type

Article

Publication Date

1-2017

Notes/Citation Information

Published in The Journal of Nutritional Biochemistry, v. 39, p. 169-179.

© 2016 Elsevier Inc. All rights reserved.

This manuscript version is made available under the CC‐BY‐NC‐ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/.

The document available for download is the author's post-peer-review final draft of the article.

Digital Object Identifier (DOI)

https://doi.org/10.1016/j.jnutbio.2016.10.006

Funding Information

This study was funded in part by the Intramural Research program of the National Institute on Aging, NIH.

Repository Citation

Swomley, Aaron M.; Triplett, Judy C.; Keeney, Jeriel T.; Warrier, Govind; Pearson, Kevin J.; Mattison, Julie A.; de Cabo, Rafael; Cai, Jian; Klein, Jon B.; and Butterfield, D. Allan, "Comparative Proteomic Analyses of the Parietal Lobe from Rhesus Monkeys Fed a High-Fat/Sugar Diet With and Without Resveratrol Supplementation, Relative to a Healthy Diet: Insights Into the Roles of Unhealthy Diets and Resveratrol on Function" (2017). Chemistry Faculty Publications. 150.
https://uknowledge.uky.edu/chemistry_facpub/150