Abstract

Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMR and mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.

Document Type

Article

Publication Date

6-7-2017

Notes/Citation Information

Published in The Journal of Biological Chemistry, v. 292, no. 28, p. 11601-11609.

This research was originally published in The Journal of Biological Chemistry. Ronald C. Bruntz, Andrew N. Lane, Richard M. Higashi, and Teresa W.-M. Fan. Exploring Cancer Metabolism Using Stable Isotope-Resolved Metabolomics (SIRM). J. Biol. Chem. 2017; 292:11601-11609. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

The copyright holder has granted the permission for posting the article here.

Digital Object Identifier (DOI)

https://doi.org/10.1074/jbc.R117.776054

Funding Information

This work was supported in part by National Institutes of Health Grants T32CA165990 (to R. C. B.), 1R01ES022191-01 (to T. W. M. F. and R. M. H.), and 1P01CA163223-01A1 (to A. N. L. and T. W. M. F.).

Share

COinS