Abstract
Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMR and mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.
Document Type
Article
Publication Date
6-7-2017
Digital Object Identifier (DOI)
https://doi.org/10.1074/jbc.R117.776054
Funding Information
This work was supported in part by National Institutes of Health Grants T32CA165990 (to R. C. B.), 1R01ES022191-01 (to T. W. M. F. and R. M. H.), and 1P01CA163223-01A1 (to A. N. L. and T. W. M. F.).
Repository Citation
Bruntz, Ronald C.; Lane, Andrew N.; Higashi, Richard M.; and Fan, Teresa W. -M., "Exploring Cancer Metabolism Using Stable Isotope-Resolved Metabolomics (SIRM)" (2017). Center for Environmental and Systems Biochemistry Faculty Publications. 3.
https://uknowledge.uky.edu/cesb_facpub/3
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Biochemistry Commons, Cancer Biology Commons, Oncology Commons
Notes/Citation Information
Published in The Journal of Biological Chemistry, v. 292, no. 28, p. 11601-11609.
This research was originally published in The Journal of Biological Chemistry. Ronald C. Bruntz, Andrew N. Lane, Richard M. Higashi, and Teresa W.-M. Fan. Exploring Cancer Metabolism Using Stable Isotope-Resolved Metabolomics (SIRM). J. Biol. Chem. 2017; 292:11601-11609. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.
The copyright holder has granted the permission for posting the article here.