US Patent Number
The presently-disclosed subject matter includes compounds that comprise an initiator and an active agent that is covalently bonded to the initiator through a ring-opening polymerization process, an atom-transfer radical polymerization process, a Michael addition reaction, or a ring-opening metathesis polymerization process. In some embodiments the active agent includes simvastatin. The presently-disclosed subject matter also includes methods for making the compositions and methods for using the compositions to treat tissue wounds.
University of Kentucky Research Foundation, Lexington, KY (US)
Puleo, David A.; Dziubla, Thomas D.; and Asafo-Adjei, Theodora, "Polymeric Prodrug" (2016). Biomedical Engineering Faculty Patents. 13.