Diffuse Optical Measurements of Head and Neck Tumor Hemodynamics for Early Prediction of Chemoradiation Therapy Outcomes

Lixin Dong, University of Kentucky
Mahesh Kudrimoti, University of Kentucky
Daniel Irwin, University of Kentucky
Li Chen, University of Kentucky
Sameera Kumar, University of Kentucky
Yu Shang, University of Kentucky
Chong Huang, University of Kentucky
Ellis L. Johnson, University of Kentucky
Scott D. Stevens, University of Kentucky
Brent J. Shelton, University of Kentucky
Guoqiang Yu, University of Kentucky

Published in Journal of Biomedical Optics, v. 21, no. 8, article 085004, p. 1-11.

Lixin Dong, Mahesh Kudrimoti, Daniel Irwin, Li Chen, Sameera Kumar, Yu Shang, Chong Huang, Ellis L. Johnson, Scott D. Stevens, Brent J. Shelton, Guoqiang Yu, "Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes," Journal of Biomedical Optics 21(8), 085004 (August 26, 2016). DOI: http://dx.doi.org/10.1117/1.JBO.21.8.085004

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This study used a hybrid near-infrared diffuse optical instrument to monitor tumor hemodynamic responses to chemoradiation therapy for early prediction of treatment outcomes in patients with head and neck cancer. Forty-seven patients were measured once per week to evaluate the hemodynamic status of clinically involved cervical lymph nodes as surrogates for the primary tumor response. Patients were classified into two groups: complete response (CR) (n = 29) and incomplete response (IR) (n = 18). Tumor hemodynamic responses were found to be associated with clinical outcomes (CR/IR), wherein the associations differed depending on human papillomavirus (HPV-16) status. In HPV-16 positive patients, significantly lower levels in tumor oxygenated hemoglobin concentration ([HbO2]) at weeks 1 to 3, total hemoglobin concentration at week 3, and blood oxygen saturation (StO2) at week 3 were found in the IR group. In HPV-16 negative patients, significantly higher levels in tumor blood flow index and reduced scattering coefficient (μ′s) at week 3 were observed in the IR group. These hemodynamic parameters exhibited significantly high accuracy for early prediction of clinical outcomes, within the first three weeks of therapy, with the areas under the receiver operating characteristic curves (AUCs) ranging from 0.83 to 0.96.