The optoelectronic sensor OPT101 have merits in advanced optoelectronic response characteristics at wavelength range for medical near-infrared spectroscopy and small-size chip design with build-in trans-impedance amplifier. Our lab is devoted to developing a series of portable near-infrared spectroscopy (NIRS) devices embedded with OPT101 for applications in intensive care unit clinics, based on NIRS principle. Here we review the characteristics and advantages of OPT101 relative to clinical NIRS instrumentation, and the most recent achievements, including early-diagnosis and therapeutic effect evaluation of thrombus, noninvasive monitoring of patients' shock severity, and fatigue evaluation. The future prospect on OPT101 improvements in noninvasive clinical applications is also discussed.

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Published in Sensors, v. 17, issue 8, 1701, p. 1-13.

© 2017 by the authors. Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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We thank the supports of the One University One Zone Growth Fund (No. A03013023001019), the Central University Basic Scientific Research Project Business Expenses (No. ZYGX2016J052), CAMS Innovation Fund for Medical Sciences (No. 2016-I2M-3-023), and National Natural Science Fund Projects (No. 61675039).