Author ORCID Identifier

Date Available


Year of Publication


Degree Name

Master of Science in Biomedical Engineering

Document Type

Master's Thesis




Biomedical Engineering

First Advisor

Dr. Ramkumar T. Annamalai


Currently, there is no standard in vitro model for studying the effects of mechanical stimulation on muscle in type II diabetes. Existing models primarily utilize electrical stimulation, which does not fully recapitulate the effects of exercise. In this thesis, we create a standardized in vitro model of murine muscle that can recapitulate the benefits seen in exercise when mechanically stimulated. Moreover, we show that a type II diabetes environment has similar effects on the muscle in vitro as well as in vivo.

Digital Object Identifier (DOI)

Funding Information

This study was supported by the National Institute of General Medicine through the Center of Biomedical Research Excellence in Pharmaceutical Research and Innovation (P20GM130456) grant from the years of 2021 to 2023.