3-DIMENSIONAL MUSCLE CONSTRUCTS: USING HYDROGELS IN ORDER TO MODEL THE EFFECTS OF EXERCISE IN DISEASE CONDITIONS
Author ORCID Identifier
Year of Publication
Master of Science in Biomedical Engineering
Dr. Ramkumar T. Annamalai
Currently, there is no standard in vitro model for studying the effects of mechanical stimulation on muscle in type II diabetes. Existing models primarily utilize electrical stimulation, which does not fully recapitulate the effects of exercise. In this thesis, we create a standardized in vitro model of murine muscle that can recapitulate the benefits seen in exercise when mechanically stimulated. Moreover, we show that a type II diabetes environment has similar effects on the muscle in vitro as well as in vivo.
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This study was supported by the National Institute of General Medicine through the Center of Biomedical Research Excellence in Pharmaceutical Research and Innovation (P20GM130456) grant from the years of 2021 to 2023.
McHargue, Mark, "3-DIMENSIONAL MUSCLE CONSTRUCTS: USING HYDROGELS IN ORDER TO MODEL THE EFFECTS OF EXERCISE IN DISEASE CONDITIONS" (2023). Theses and Dissertations--Biomedical Engineering. 78.
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