Author ORCID Identifier
Date Available
5-14-2023
Year of Publication
2023
Degree Name
Master of Science in Biomedical Engineering
Document Type
Master's Thesis
College
Engineering
Department/School/Program
Biomedical Engineering
First Advisor
Dr. Ramkumar T. Annamalai
Abstract
Currently, there is no standard in vitro model for studying the effects of mechanical stimulation on muscle in type II diabetes. Existing models primarily utilize electrical stimulation, which does not fully recapitulate the effects of exercise. In this thesis, we create a standardized in vitro model of murine muscle that can recapitulate the benefits seen in exercise when mechanically stimulated. Moreover, we show that a type II diabetes environment has similar effects on the muscle in vitro as well as in vivo.
Digital Object Identifier (DOI)
https://doi.org/10.13023/etd.2023.238
Funding Information
This study was supported by the National Institute of General Medicine through the Center of Biomedical Research Excellence in Pharmaceutical Research and Innovation (P20GM130456) grant from the years of 2021 to 2023.
Recommended Citation
McHargue, Mark, "3-DIMENSIONAL MUSCLE CONSTRUCTS: USING HYDROGELS IN ORDER TO MODEL THE EFFECTS OF EXERCISE IN DISEASE CONDITIONS" (2023). Theses and Dissertations--Biomedical Engineering. 78.
https://uknowledge.uky.edu/cbme_etds/78
Included in
Biological Engineering Commons, Biomaterials Commons, Molecular, Cellular, and Tissue Engineering Commons
