Abstract
Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190kDa subunit couples with the 130kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.
Document Type
Article
Publication Date
3-2018
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.pharmthera.2017.08.008
Funding Information
Funding was provided by NINDSR01NS091146.
Repository Citation
Davis, Stephanie M. and Pennypacker, Keith R., "The Role of the Leukemia Inhibitory Factor Receptor in Neuroprotective Signaling" (2018). Center for Advanced Translational Stroke Science Faculty Publications. 1.
https://uknowledge.uky.edu/catss_facpub/1
Notes/Citation Information
Published in Pharmacology & Therapeutics, v. 183.
© 2017 Published by Elsevier Inc.
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/.
The document available for download is the authors' post-peer-review final draft of the article.