Year of Publication
Arts and Sciences
Dr. Michael T. Bardo
The objective of the present study was to determine the effectiveness of the opioid antagonist naltrexone at reducing the consumption of EtOH and nicotine in female alcohol-preferring (P) rats. P rats have been selectively bred to have a genetic predisposition for alcohol abuse, which allows them to be used as an animal model of alcoholism. P rats readily self-administer i.v nicotine (Le et al., 2016), have EtOH consumption during adolescence that is similar to that seen in adulthood, and operantly respond for EtOH until they are impaired/intoxicated (Bell et al., 2006). Thus, P rats are a useful model for studying naltrexone’s effects on EtOH and nicotine co-use.
Hamid, Usman Z.; Maggio, Sarah E.; Saunders, Meredith A.; Nixon, Kimberly; Prendergast, Mark A.; Bell, Richard L.; and Bardo, Michael T., "Effects of Naltrexone on Alcohol and Nicotine Use in Female P Rats" (2019). Posters-at-the-Capitol Presentations. 2.