Effects of Naltrexone on Alcohol and Nicotine Use in Female P Rats

Author

Usman Z. Hamid, University of KentuckyFollow
Sarah E. Maggio, University of KentuckyFollow
Meredith A. Saunders, University of KentuckyFollow
Kimberly Nixon, University of KentuckyFollow
Mark A. Prendergast, University of KentuckyFollow
Richard L. Bell, Indiana University
Michael T. Bardo, University of KentuckyFollow

Year of Publication

2019

College

Arts and Sciences

Department/School/Program

Psychology

Faculty Mentor

Dr. Michael T. Bardo

Abstract

The objective of the present study was to determine the effectiveness of the opioid antagonist naltrexone at reducing the consumption of EtOH and nicotine in female alcohol-preferring (P) rats. P rats have been selectively bred to have a genetic predisposition for alcohol abuse, which allows them to be used as an animal model of alcoholism. P rats readily self-administer i.v nicotine (Le et al., 2016), have EtOH consumption during adolescence that is similar to that seen in adulthood, and operantly respond for EtOH until they are impaired/intoxicated (Bell et al., 2006). Thus, P rats are a useful model for studying naltrexone’s effects on EtOH and nicotine co-use.

Notes

Usman Z. Hamid participated in the Posters-at-the-Capitol event in Frankfort, KY on Feb. 21, 2019.

Recommended Citation

Hamid, Usman Z.; Maggio, Sarah E.; Saunders, Meredith A.; Nixon, Kimberly; Prendergast, Mark A.; Bell, Richard L.; and Bardo, Michael T., "Effects of Naltrexone on Alcohol and Nicotine Use in Female P Rats" (2019). Posters-at-the-Capitol Presentations. 2.
https://uknowledge.uky.edu/capitol_present/2