INTRODUCTION—Findings for genetic correlates of late-onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits.
METHODS—We evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators.
RESULTS—LOAD associations nominally differed for 4 of 21 variants; CR1 and APOE variants were significant after Bonferroni correction.
DISCUSSION—Estimates of genetic associations may differ for studies limited to clinic-only designs. Home visit capacity should be explored as a possible source of heterogeneity and potential bias in genetic studies.
Digital Object Identifier (DOI)
Study funding for the ACT study was from AG-06781 (Multiple PIs: E Larson and P Crane). Some analyses were funded by R01 AG 042437 (P Crane, PI), P50 AG05136 (LEG) and K25 AG043546 (DWF).
Refer to Web version on PubMed Central for supplementary material.
Fardo, David W.; Gibbons, Laura E.; Mukherjee, Shubhabrata; Glymour, M. Maria; McCormick, Wayne; McCurry, Susan M.; Bowen, James D.; Larson, Eric B.; and Crane, Paul K., "Impact of Home Visit Capacity on Genetic Association Studies of Late-Onset Alzheimer's Disease" (2017). Biostatistics Faculty Publications. 41.