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Abstract
It is generally accepted that many genes present in vertebrate genomes owe their origin to two whole-genome duplications that occurred deep in the ancestry of the vertebrate lineage. However, details regarding the timing and outcome of these duplications are not well resolved. We present high-density meiotic and comparative genomic maps for the sea lamprey (Petromyzon marinus), a representative of an ancient lineage that diverged from all other vertebrates ~550 million years ago. Linkage analyses yielded a total of 95 linkage groups, similar to the estimated number of germline chromosomes (1n ~ 99), spanning a total of 5570.25 cM. Comparative mapping data yield strong support for the hypothesis that a single whole-genome duplication occurred in the basal vertebrate lineage, but do not strongly support a hypothetical second event. Rather, these comparative maps reveal several evolutionarily independent segmental duplications occurring over the last 600+ million years of chordate evolution. This refined history of vertebrate genome duplication should permit more precise investigations of vertebrate evolution.
Document Type
Article
Publication Date
8-2015
Digital Object Identifier (DOI)
http://dx.doi.org/10.1101/gr.184135.114
Funding Information
This work was funded by a grant from the National Institutes of Health (R01GM104123) and supported by startup funds from the University of Kentucky Department of Biology.
Repository Citation
Smith, Jeramiah James and Keinath, Melissa C., "The Sea Lamprey Meiotic Map Improves Resolution of Ancient Vertebrate Genome Duplications" (2015). Biology Faculty Publications. 104.
https://uknowledge.uky.edu/biology_facpub/104
Supplementary Figures
Supplemental_Table_S1.xlsx (742 kB)
Supplemental Table S1
Supplemental_Table_S2.xlsx (509 kB)
Supplemental Table S2
Supplemental_Table_S3.xlsx (554 kB)
Supplemental Table S3
Supplemental_Table_S4.xlsx (44 kB)
Supplemental Table S4
Notes/Citation Information
Published in Genome Research, v. 25, no. 8, p. 1081-1090.
© 2015 Smith and Keinath
This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.