Date Available


Year of Publication


Degree Name

Master of Science (MS)

Document Type

Master's Thesis


Arts and Sciences



First Advisor

Dr. Jeffrey L. Osborn


Postpartum hypertension (PPHT) is a hypertensive disorder of the puerperium that occurs in women at a rate between 0.8-28% although the exact incidence is unknown due primarily to its transient presentation during a time of reduced medical supervision. The etiology of PPHT is currently unknown with no present experimental animal model. We present the African green monkey (Chlorocebus aethiops sabaeus; AGM) as a potentially translational NHP model of PPHT in humans. AGMs were identified as PPHT using Doppler sphygmomanometry and American Heart Association standards of hypertension for systolic blood pressure (systolic blood pressure > 140 mmHg). Disease characteristics were determined utilizing the following measures: water intakes, urinary excretion rates, and plasma osmolalities were used to assess water balance and urinary Na+/K+ and protein excretion rates were measured as assessments of renal function. The results indicated potential roles for the renin-angiotensin-aldosterone system, antidiuretic hormone, or atrial natriuretic peptide-related dysfunction in the development of PPHT. Concomitant proteinuria potentially indicated the presence of postpartum preeclampsia. The AGM model of PPHT recapitulates many of the potential etiologies of human PPHT.

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