Date Available

8-4-2021

Year of Publication

2021

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College

Arts and Sciences

Department/School/Program

Biology

Advisor

Dr. Jeffrey L. Osborn

Abstract

Postpartum hypertension (PPHT) is a hypertensive disorder of the puerperium that occurs in women at a rate between 0.8-28% although the exact incidence is unknown due primarily to its transient presentation during a time of reduced medical supervision. The etiology of PPHT is currently unknown with no present experimental animal model. We present the African green monkey (Chlorocebus aethiops sabaeus; AGM) as a potentially translational NHP model of PPHT in humans. AGMs were identified as PPHT using Doppler sphygmomanometry and American Heart Association standards of hypertension for systolic blood pressure (systolic blood pressure > 140 mmHg). Disease characteristics were determined utilizing the following measures: water intakes, urinary excretion rates, and plasma osmolalities were used to assess water balance and urinary Na+/K+ and protein excretion rates were measured as assessments of renal function. The results indicated potential roles for the renin-angiotensin-aldosterone system, antidiuretic hormone, or atrial natriuretic peptide-related dysfunction in the development of PPHT. Concomitant proteinuria potentially indicated the presence of postpartum preeclampsia. The AGM model of PPHT recapitulates many of the potential etiologies of human PPHT.

Digital Object Identifier (DOI)

https://doi.org/10.13023/etd.2021.363

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