Abstract

Twist is a key transcription factor for Epithelial-mesenchymal transition (EMT), which is a cellular de-differentiation program that promotes invasion and metastasis, confers tumor cells with cancer stem cell (CSC)-like characteristics, and increases therapeutic resistance. However, the mechanisms that facilitate the functions of Twist remain unclear. Here we report that Twist overexpression increased expression of PAR1, an upstream regulator of the Hippo pathway; PAR1 promotes invasion, migration, and CSC-like properties in breast cancer by activating the transcriptional co-activator TAZ. Our study indicates that Hippo pathway inhibition is required for the increased migratory and invasiveness ability of breast cancer cells in Twist-mediated EMT.

Document Type

Article

Publication Date

4-20-2016

Notes/Citation Information

Published in Scientific Reports, v. 6, article no. 24606, p. 1-10.

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Digital Object Identifier (DOI)

https://doi.org/10.1038/srep24606

Funding Information

This work was supported in part by grants from NIH (RO1s CA125454 and CA188118), DOD Breakthrough Award (BC140733P1), Mary Kay Ash Foundation (to B.P. Zhou), National Natural Science Foundation of China (No. 81402434 to Y. Wang, and No. 81402432 to J. Liu), and the Zhejiang Provincial Natural Science Foundation of China (No. LQ14H280002) (to Y. Wang).

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