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Abstract
Cell wall glycopolymers on the surface of Gram-positive bacteria are fundamental to bacterial physiology and infection biology. Here we identify gacH, a gene in the Streptococcus pyogenes group A carbohydrate (GAC) biosynthetic cluster, in two independent transposon library screens for its ability to confer resistance to zinc and susceptibility to the bactericidal enzyme human group IIA-secreted phospholipase A
Document Type
Article
Publication Date
5-1-2019
Digital Object Identifier (DOI)
https://doi.org/10.1038/s41589-019-0251-4
Repository Citation
Edgar, Rebecca J; van Hensbergen, Vincent P; Ruda, Alessandro; Turner, Andrew G; Deng, Pan; Le Breton, Yoann; El-Sayed, Najib M; Belew, Ashton T; McIver, Kevin S; McEwan, Alastair G; Morris, Andrew J; Lambeau, Gérard; Walker, Mark J; Rush, Jeffrey S.; Korotkov, Konstantin V; Widmalm, Göran; van Sorge, Nina M; and Korotkova, Natalia, "Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides." (2019). Molecular and Cellular Biochemistry Faculty Publications. 201.
https://uknowledge.uky.edu/biochem_facpub/201
Notes/Citation Information
Nat Chem Biol. 2019 May;15(5):463-471