Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides.

Authors

Rebecca J Edgar
Vincent P van Hensbergen
Alessandro Ruda
Andrew G Turner
Pan Deng
Yoann Le Breton
Najib M El-Sayed
Ashton T Belew
Kevin S McIver
Alastair G McEwan
Andrew J Morris
Gérard Lambeau
Mark J Walker
Jeffrey S. Rush, University of KentuckyFollow
Konstantin V Korotkov
Göran Widmalm
Nina M van Sorge
Natalia Korotkova

Abstract

Cell wall glycopolymers on the surface of Gram-positive bacteria are fundamental to bacterial physiology and infection biology. Here we identify gacH, a gene in the Streptococcus pyogenes group A carbohydrate (GAC) biosynthetic cluster, in two independent transposon library screens for its ability to confer resistance to zinc and susceptibility to the bactericidal enzyme human group IIA-secreted phospholipase A

Document Type

Article

Publication Date

5-1-2019

Notes/Citation Information

Nat Chem Biol. 2019 May;15(5):463-471

Digital Object Identifier (DOI)

https://doi.org/10.1038/s41589-019-0251-4

Repository Citation

Edgar, Rebecca J; van Hensbergen, Vincent P; Ruda, Alessandro; Turner, Andrew G; Deng, Pan; Le Breton, Yoann; El-Sayed, Najib M; Belew, Ashton T; McIver, Kevin S; McEwan, Alastair G; Morris, Andrew J; Lambeau, Gérard; Walker, Mark J; Rush, Jeffrey S.; Korotkov, Konstantin V; Widmalm, Göran; van Sorge, Nina M; and Korotkova, Natalia, "Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides." (2019). Molecular and Cellular Biochemistry Faculty Publications. 201.
https://uknowledge.uky.edu/biochem_facpub/201