Abstract

Studies assessing depression as a mediating factor between adverse childhood experiences (ACEs) and subjective cognitive decline (SCD) are lacking. Therefore, the aims of this study were to: (1) determine the mediating role of depression in the association between ACEs and SCD; and (2) assess the moderating role of gender. Data were obtained from the 2023 Behavioral Risk Factor Surveillance Study (BRFSS) survey (N = 38,600). Crude and adjusted path analyses were used to determine the mediating role of depression between ACEs and SCD. Adjusted analyses controlled for sociodemographic confounders. ACEs were positively associated with depression (B = 0.129, p < 0.001), depression was positively associated with SCD (B = 0.224, p < 0.001), and ACEs were positively associated with SCD (B = 0.066, p < 0.001). Depression mediated the association between ACEs and SCD in the overall population (B = 0.029, p < 0.001), and for men (B = 0.025, p < 0.001) and women (B = 0.032, p < 0.001). Intervention programs addressing ACEs may reduce depression and help with cognition for men and women.

Document Type

Article

Publication Date

2025

Notes/Citation Information

© The Author(s) 2025

Digital Object Identifier (DOI)

https://doi.org/10.1177/07334648251386108

Funding Information

The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grant K01MH115794 and R34MH137775 from the National Institute of Mental Health to Dr Brown and K99AG078286 from the National Institute on Aging to Dr Esiaka. Dr Viswanathan is an independent researcher without financial conflicts who contributed to this article.

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