Abstract
Spinal cord stimulation has seen unprecedented growth in new technology in the 50 years since the first subdural implant. As we continue to grow our understanding of spinal cord stimulation and relevant mechanisms of action, novel questions arise as to electrical dosing optimization. Programming adjustment — dose titration — is often a process of trial and error that can be time-consuming and frustrating for both patient and clinician. In this report, we review the current preclinical and clinical knowledge base in order to provide insights that may be helpful in developing more rational approaches to spinal cord stimulation dosing. We also provide key conclusions that may help in directing future research into electrical dosing, given the advent of newer waveforms outside traditional programming parameters.
Document Type
Review
Publication Date
9-7-2021
Digital Object Identifier (DOI)
https://doi.org/10.2147/JPR.S323372
Funding Information
Support for development of this manuscript was provided by Abbott.
Repository Citation
Chakravarthy, Krishnan; Reddy, Rajiv; Al-Kaisy, Adnan; Yearwood, Thomas; and Grider, Jay S., "A Call to Action toward Optimizing the Electrical Dose Received by Neural Targets in Spinal Cord Stimulation Therapy for Neuropathic Pain" (2021). Anesthesiology Faculty Publications. 14.
https://uknowledge.uky.edu/anesthesiology_facpub/14
Notes/Citation Information
Published in Journal of Pain Research, v. 14.
© 2021 Chakravarthy et al.
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