US Patent Number
6072045
Publication Date
6-6-2000
Abstract
Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous isoprenoid synthase. Also disclosed is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned homologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
Assignees
Board of Trustees of the University of Kentucky, Lexington Ky.
Application Number
09/134,699
Filing Date
08/14/1998
Recommended Citation
Chappell, Joseph and Back, Kyoungwhan, "Chemical Isoprenoid Synthases and Uses Thereof" (2000). Pharmaceutical Sciences Faculty Patents. 100.
https://uknowledge.uky.edu/ps_patents/100
