Abstract
Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.
Document Type
Review
Publication Date
5-11-2010
Digital Object Identifier (DOI)
http://dx.doi.org/10.3390/ph3051411
Repository Citation
Gu, Qihai and Lee, Lu-Yuan, "Acid-Sensing Ion Channels and Pain" (2010). Physiology Faculty Publications. 50.
https://uknowledge.uky.edu/physiology_facpub/50
Notes/Citation Information
Published in Pharmaceuticals, v. 3, no. 5, p. 1411-1425.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.