Vectors and Methods for Enhanced Cell Longevity and Protein Expression

Authors

Bruce A. Webb, University of KentuckyFollow
Jeremy Kroemer, University of Kentucky

US Patent Number

7629160

Publication Date

12-8-2009

Abstract

It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for protein production. The inventors have discovered that the expression of P-ank-1 and I²-ank-3 proteins in cell culture has increased the cells' longevity and capacity for endogenous and/or heterologous target protein production. Specifically, the present invention relates to the enhanced expression of endogenous and/or heterologous target proteins/polypeptides in recombinant cells that are also expressing P-ank-1 and/or I²-ank-3 protein compared to expression host cells that are not expressing P-ank-1 and/or I²-ank-3 protein.

Assignees

University of Kentucky Research Foundation, Lexington, KY (US)

Application Number

11/016,871

Filing Date

12/21/2004

Recommended Citation

Webb, Bruce A. and Kroemer, Jeremy, "Vectors and Methods for Enhanced Cell Longevity and Protein Expression" (2009). Entomology Faculty Patents. 3.
https://uknowledge.uky.edu/entomology_patents/3