US Patent Number
Sites on antibodies having affinity for photoaffinity compounds, in particular purine or azidopurine containing compounds are taught. Such photoaffinity sites are contained on a conserved region of different antibody molecules. These sites provide for the site-specific attachment of nucleotide photoaffinity compounds to antibodies, e.g., ATP- or GTP-analog photoaffinity compounds by photochemical means. These nucleotide photoaffinity compounds may additionally be attached to molecules having a desired therapeutic or diagnostic activity, and the resultant conjugates used as diagnostics or therapeutics.
University of Kentucky Research Foundation, Lexington, Ky.
Haley, Boyd E.; Köhler, Heinz; Rajagopalan, Krishnan; and Pavlinkova, Gabriela, "Nucleotide or Nucleoside Photoaffinity Compound Modified Antibodies, Methods for Their Manufacture and Use Thereof as Diagnostics and Therapeutics" (1998). Chemistry Faculty Patents. Paper 29.