Nucleotide or Nucleoside Photoaffinity Compound Modified Antibodies, Methods for Their Manufacture and Use Thereof as Diagnostics and Therapeutics

Authors

Boyd E. Haley, University of Kentucky
Heinz Köhler, University of KentuckyFollow
Krishnan Rajagopalan, University of Kentucky
Gabriela Pavlinkova, University of Kentucky

US Patent Number

5800991

Publication Date

9-1-1998

Abstract

Sites on antibodies having affinity for photoaffinity compounds, in particular purine or azidopurine containing compounds are taught. Such photoaffinity sites are contained on a conserved region of different antibody molecules. These sites provide for the site-specific attachment of nucleotide photoaffinity compounds to antibodies, e.g., ATP- or GTP-analog photoaffinity compounds by photochemical means. These nucleotide photoaffinity compounds may additionally be attached to molecules having a desired therapeutic or diagnostic activity, and the resultant conjugates used as diagnostics or therapeutics.

Assignees

University of Kentucky Research Foundation, Lexington, Ky.

Application Number

681,432

Filing Date

07/23/1996

Recommended Citation

Haley, Boyd E.; Köhler, Heinz; Rajagopalan, Krishnan; and Pavlinkova, Gabriela, "Nucleotide or Nucleoside Photoaffinity Compound Modified Antibodies, Methods for Their Manufacture and Use Thereof as Diagnostics and Therapeutics" (1998). Chemistry Faculty Patents. 29.
https://uknowledge.uky.edu/chemistry_patents/29