Predictors of Permanent and Temporary Motor Deficits in Patients Undergoing Glioma Resection

Authors

• Brian J. Conway, Medical College of WisconsinFollow
• Stephanie A. Armstrong, Medical College of Wisconsin
• Nada Botros, Medical College of Wisconsin
• Sergey Tarima, University of KentuckyFollow
• Max O. Krucoff, Medical College of Wisconsin

Abstract

Objective: To identify predictors of permanent and temporary motor deficits in patients undergoing glioma resection. Methods: A literature search accessed the databases Ovid Medline, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature/EBSCO, PsychInfo, Cochrane, and Wiley for studies reporting motor outcomes following surgical resection of glioma. Outcomes were stratified by patient/tumor characteristics, preoperative condition, and intraoperative factors for both permanent and temporary motor deficits. Generalized estimating equations were used to generate odds ratios. Results: A total of 1332 titles and abstracts were reviewed resulting in the evaluation of 261 full-text articles. Data were extracted from 67 studies including 2616 patients with 371 (14%) developing permanent postoperative motor deficits, 465 (18%) developing temporary deficits, and the remaining 1780 (68%) having no deficit. Preoperative deficit was the most significant predictor of permanent postoperative motor deficit (odds ratio [OR] 6.40, confidence interval [CI] 2.82–14.5, P < 0.0001), while high preoperative Karnofsky Performance Scale (OR 0.98, CI 0.97–0.99, P < 0.001) and subcortical tumor location (OR 0.14, C 0.030–0.62, P = 0.001) had a lower odds of a permanent deficit. Intraoperative motor-evoked potential changes was a significant predictor of both permanent (OR 5.18, CI 1.99–13.5, P = 0.00075) and temporary (OR 9.44, CI 2.78–32.0, P = 0.0003) motor deficits. Conclusions: Preoperative motor deficits were the most significant predictors of persistent or worsening postoperative motor deficits. Intraoperative motor-evoked potential changes were associated with both permanent and temporary deficits. High Karnofsky Performance Scale and subcortical tumor location had lower odds of permanent motor deficits.

Document Type

Article

Publication Date

8-1-2025

Notes/Citation Information

Publisher Copyright: © 2025 The Author(s)

Digital Object Identifier (DOI)

10.1016/j.wneu.2025.124200

Archival?

Archival

Repository Citation

Conway, Brian J.; Armstrong, Stephanie A.; Botros, Nada; Tarima, Sergey; and Krucoff, Max O., "Predictors of Permanent and Temporary Motor Deficits in Patients Undergoing Glioma Resection" (2025). Biostatistics Faculty Publications. 111.
https://uknowledge.uky.edu/biostatistics_facpub/111