US Patent Number
Various embodiments provide methods and related compositions for increasing the population size of hematopoietic stem cells (HSCs) in patients that may benefit from reconstitution of stem cells and/or differentiated cells of the blood lineage. The present methods enable the production of HSCs ex vivo and in vivo by reducing latexin expression and/or latexin activity within HSC exposed to various antagonists. Inhibition of latexin expression and/or latexin activity by various antagonists can promote HSC proliferation and/or inhibit HSC apoptosis. Antagonists that can reduce latexin expression and/or latexin activity can be utilized to regenerate endogenous HSCs within patients affected with disorders, diseases, cancers, or therapies for such conditions, that result in the depletion or reduction in HSCs.
University of Kentucky Research Foundation, Lexington, KY (US)
Van Zant, Gary and Liang, Ying, "Ex Vivo and In Vivo Methods and Related Compositions for Generating Hematopoietic Stem Cell Populations" (2012). Toxicology and Cancer Biology Faculty Patents. 1.