Date Available
7-23-2022
Year of Publication
2020
Degree Name
Doctor of Philosophy (PhD)
Document Type
Doctoral Dissertation
College
Arts and Sciences
Department/School/Program
Statistics
First Advisor
Dr. Mai Zhou
Second Advisor
Dr. Jianrong Wu
Abstract
The statistical methods are widely needed to support the clinical and biomedical research. The innovation of medical science often poses challenges on the methodology development of statistics. In this dissertation, we illustrated the research motivation and developed some new methods to existing problems in medical study. In the first part, we proposed to use two-sample empirical likelihood methods for comparing two diagnostic biomarkers by area under the ROC curve. In the second part, we proposed new test statistics and sample size formulae for cancer immunotherapy trial design with delayed treatment eect and long-term survivors. Simulation studies are conducted to compare the performance of proposed methods to existing methods. Real data examples are used to illustrate the application of proposed methods.
Digital Object Identifier (DOI)
https://doi.org/10.13023/etd.2020.309
Recommended Citation
Ding, Xue, "STATISTICAL METHODS IN CANCER CLINICAL TRIAL AND BIOMEDICAL RESEARCH" (2020). Theses and Dissertations--Statistics. 49.
https://uknowledge.uky.edu/statistics_etds/49
