Plasma neuronal exosomal levels of pathogenic Alzheimer's disease (AD) proteins, cellular survival factors, and lysosomal proteins distinguish AD patients from control subjects, but changes in these exosomal proteins associated with normal aging have not been described for cognitively intact subjects. Plasma neuronal exosomal levels of P-T181-tau, P-S396-tau, Aβ1-42, cathepsin D, repressor element 1-silencing transcription factor, and neurogranin were quantified longitudinally in cognitively intact older adults using two samples collected at 3- to 11-year intervals. Except for P-S396-tau, exosomal protein levels changed significantly with aging, but were largely outside the range observed in AD patients.
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This study was partially supported by NIA P30 AG028383 (ELA, GAJ), NIA P30 AG10124 (JQT), the BAND2 consortium of The Michael J. Fox Foundation for Parkinson’s Research, Alzheimer’s Association, Alzheimer’s Research UK, and the Weston Brain Institute (EJG). Assay development was supported by an unrestricted grant from Nanosomix, Inc. (EJG).
Abner, Erin L.; Jicha, Gregory A.; Shaw, Leslie M.; Trojanowski, John Q.; and Goetzl, Edward J., "Plasma Neuronal Exosomal Levels of Alzheimer's Disease Biomarkers in Normal Aging" (2016). Sanders-Brown Center on Aging Faculty Publications. 73.