Year of Publication

2015

Degree Name

Master of Science (MS)

Document Type

Master's Thesis

College

Arts and Sciences

Department

Psychology

First Advisor

Dr. Michael T. Bardo

Second Advisor

Dr. Joshua S. Beckmann

Abstract

Memory plays an important role in defining how one behaves. The neurobiological mechanisms of memory have been studied extensively in animal models and the NMDA glutamate receptor has been identified to play an important role in the consolidation and reconsolidation of appetitive memories. Certain memories, depending on what was learned, can function differently and can be more difficult to disrupt based on a number of factors. Currently, no study has examined whether or not a reward-predictive stimulus attributed with incentive value is more difficult to disrupt than a stimulus that functions as a general reward-predictor. To determine the role of the NMDA receptor on memory consolidation with different functioning reward-predictive stimuli rats underwent a Pavlovian conditioned approach, where a post-session NMDA receptor antagonist was administered daily. Furthermore, to determine the role of the NMDA receptor on memory reconsolidation, another set of rats were trained on a Pavlovian conditioned approach task, after training was complete rats were presented with a reward-predictive stimuli followed by an administration of a NMDA receptor antagonist and then re-tested.

Digital Object Identifier (DOI)

http://dx.doi.org/10.13023/ETD.2016.004

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