Date Available


Year of Publication


Degree Name

Master of Science (MS)

Document Type

Master's Thesis


Arts and Sciences



First Advisor

Dr. Chana K. Akins


Estrogens seem to play a role in the locomotor activating effects of cocaine. Japanese quail provide a good model for hormonal manipulation as alterations of their photoperiod controls hormone levels. The current study aims to examine the role of early life photoperiod manipulation in cocaine-induced behavioral sensitization in quail. It was expected that if quail were raised on a short photoperiod, they would have a reduction in gonadal hormones and this reduction in hormones would affect the acquisition of cocaine-induced behavioral sensitization. Quail were raised on an 8L:16D or a 16L:8D light cycle. Following 2 days of habituation, quail were administered saline, 5 mg/kg, or 10 mg/kg cocaine for 10 days. Restricted photoperiods in early life were correlated to lower gonadal hormone levels in females and males. Male quail raised on the short-light cycle developed a sensitized response to 10 mg/kg cocaine. Female quail raised on the short- or long-photoperiod developed behavioral sensitization to 5 mg/kg cocaine. Furthermore, early life reduction in estradiol in females modulated the amount of activity on day 10 of cocaine treatment. The current research extends previous research by finding a possible early life gonadal hormone control of behavioral sensitization in the quail.

Digital Object Identifier (DOI)