Nowadays, biocatalysts have received much more attention in chemistry regarding their potential to enable high efficiency, high yield, and eco-friendly processes for a myriad of applications. Nature’s vast repository of catalysts has inspired synthetic chemists. Furthermore, the revolutionary technologies in bioengineering have provided the fast discovery and evolution of enzymes that empower chemical synthesis. This article attempts to deliver a comprehensive overview of the last two decades of investigation into enzymatic reactions and highlights the effective performance progress of bio-enzymes exploited in organic synthesis. Based on the types of enzymatic reactions and enzyme commission (E.C.) numbers, the enzymes discussed in the article are classified into oxidoreductases, transferases, hydrolases, and lyases. These applications should provide us with some insight into enzyme design strategies and molecular mechanisms.
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This work was carried by the Louisiana Board of Regents, grant number LEQSF-EPS (2020)-SURE-226, and the Centenary College of Louisiana Charlton H. Lyons Summer Research Award. The publication of this article was funded by the Centenary College of Louisiana.
Mu, Ruipu; Wang, Zhaoshuai; Wamsley, Max C.; Duke, Colbee N.; Lii, Payton H.; Epley, Sarah E.; Todd, London C.; and Roberts, Patty J., "Application of Enzymes in Regioselective and Stereoselective Organic Reactions" (2020). Pharmaceutical Sciences Faculty Publications. 147.