High-density lipoprotein (HDL) is a key component of circulating blood and plays essential roles in regulation of vascular endothelial function and immunity. Clinical data demonstrate that HDL levels drop by 40-70% in septic patients, which is associated with a poor prognosis. Experimental studies using Apolipoprotein A-I (ApoAI) null mice showed that HDL deficient mice are susceptible to septic death, and overexpressing ApoAI in mice to increase HDL levels protects against septic death. These clinical and animal studies support our hypothesis that a decrease in HDL level is a risk factor for sepsis, and raising circulating HDL levels may provide an efficient therapy for sepsis. In this review, we discuss the roles of HDL in sepsis and summarize the efforts of using synthetic HDL as a potential therapy for sepsis.
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This publication was made possible by Grant Number R01GM113832 (to X-AL and AS) from NIGMS/NIH, AHA 13SDG17230049 (AS), and NIH T32 GM008353 (EM).
Morin, Emily E.; Guo, Ling; Schwendeman, Anna; and Li, Xiang-An, "HDL in Sepsis - Risk Factor and Therapeutic Approach" (2015). Pediatrics Faculty Publications. 194.