US Patent Number
A method of modulating cytokine mediated hepatic injury by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, deltorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade in a murine model of septic shock. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
University of Kentucky Research Foundation, Lexington, KY (US), Zymogenetics, Seattle, WA (US)
Oeltgen, Peter R.; McClain, Craig J.; Barve, Shirish; and Bishop, Paul D., "Method for Treating Cytokine Mediated Hepatic Injury" (2002). Graduate Center for Nutritional Sciences Faculty Patents. 24.