Biomaterial injection is a potential new therapy for augmenting ventricular mechanics after myocardial infarction (MI). Recent in vivo studies have demonstrated that hydrogel injections can mitigate the adverse remodeling due to MI. More importantly, the material properties of these injections influence the efficacy of the therapy. The goal of the current study is to explore the interrelated effects of injection stiffness and injection volume on diastolic ventricular wall stress and thickness. To achieve this, finite element models were constructed with different hydrogel injection volumes (150 µL and 300 µL), where the modulus was assessed over a range of 0.1 kPa to 100 kPa (based on experimental measurements). The results indicate that a larger injection volume and higher stiffness reduce diastolic myofiber stress the most, by maintaining the wall thickness during loading. Interestingly, the efficacy begins to taper after the hydrogel injection stiffness reaches a value of 50 kPa. This computational approach could be used in the future to evaluate the optimal properties of the hydrogel.
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This study was supported by National Institutes of Health grants R01 HL063954 (R. Gorman) and R01 HL111090 (J. Burdick), as well as a grant from the National Science Foundation CMMI-1538754 (J. Wenk).
Wang, Hua; Rodell, Christopher B.; Lee, Madonna E.; Dusaj, Neville N.; Gorman, Joseph H. III; Burdick, Jason A.; Gorman, Robert C.; and Wenk, Jonathan F., "Computational Sensitivity Investigation of Hydrogel Injection Characteristics for Myocardial Support" (2017). Mechanical Engineering Faculty Publications. 58.